2,2-Difluoro-PGF2 analogs

ABSTRACT

2,2-Difluoro prostaglandin E, F.sub.α, F.sub.β, A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.

The present application is a divisional application of Ser. No. 552,708,filed Feb. 24, 1975, now issued as U.S. Pat. No. 4,001,300, on Jan. 4,1977.

The present invention relates to prostaglandin analogs for which theessential material constituting a disclosure therefor is incorporated byreference here from U.S. Pat. No. 4,001,300, issued Jan. 4, 1977.

I claim:
 1. A compound of the formula ##STR1## or a mixture comprisingthat compound and the enantiomer thereof, wherein g is 2 to 4,inclusive;wherein M₄ is ##STR2## or ##STR3## wherein m is 2 to 4,inclusive, wherein R₁ is hydrogen, alkyl of one to 12 carbon atoms,inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2,or 3 chloro, alkyl of one to 4 carbon atoms, inclusive, or apharmacologically acceptable cation, ##STR4##
 2. A compound according toclaim 1, wherein M₄ is ##STR5##
 3. A compound according to claim 2,wherein g is
 2. 4. A compound according to claim 3, wherein m is
 3. 5.2,2,16,16-Tetrafluoro-PGF₂ α, a compound according to claim 4, whereinR₁ is hydrogen.
 6. 2,2,16,16-Tetrafluoro-PGF₂ α, methyl ester, acompound according to claim 4, wherein R₁ is methyl.